Dose finding in aspergillosis

451Case Finding for Invasive Aspergillosis in Children

Background. Invasive aspergillosis (IA) continues to pose a serious threat to immunocompromised children. We sought to determine the recent epidemiology of IA and compare the utility of multiple diagnostic strategies for IA case finding. Methods. A retrospective case series of patients ≤18 years of age with proven, probable or possible IAdiagnosed from 2004-2013 was performed at NewYork-Presbyt...

Pulmonary Aspergillosis in Ostrich

Best Intention Designs in Dose–finding Studies

In the dose–finding setting, we discuss and compare adaptive designs, including those which allocate each new patient (or a cohort of patients) to the dose currently viewed as the best one, for example, the seemingly most efficacious. We call this type of allocation “best intention” designs and found that, similar to other areas of life, the best intention may pave the road to rather disastrous...

Mycotoxicoses in veterinary medicine: Aspergillosis and penicilliosis

Molds and mycotoxins are contaminants of animal feed causing spoilage and clinical intoxication. Animal exposure to mycotoxins reflects diet composition with major differences occurring between animals kept predominantly of pastures, i.e. ruminants and horses, and those consuming formulated feed like pigs and poultry. Mixed feeds are composed of several ingredients, often sourced from different...

Phase II dose escalation study of caspofungin for invasive Aspergillosis.

Our objective was to evaluate the maximum tolerated dose of caspofungin for invasive aspergillosis (IA). The safety and pharmacokinetics of escalating dosages of caspofungin were investigated in IA. Eight patients each received caspofungin 70, 100, 150, or 200 mg once a day (QD). Dose-limiting toxicity (DLT) was defined as the same non-hematological treatment-related adverse event of grade ≥ 4 ...